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KMID : 1007320100160030142
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Journal of the Korean Society of Menopause
2010 Volume.16 No. 3 p.142 ~ p.147
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Relationship between Metabolic Syndrome and Bone Mineral Density in Middle-aged Women
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Jeon Su-Kyung
Hong Hye-Ri
Yi Kyong-Wook
Park Hyun-Tae
Shin Jung-Ho
Lee Nak-Woo
Kim Tak
Kim Hai-Joong
Hur Jun-Young
Kim Sun-Haeng
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Abstract
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Objectives: To determine the relationship between metabolic syndrome (MS) and bone mineral density (BMD) in middle-aged women.
Methods: Three hundred eight premenopausal women were included in this study, including 268 women without MS and 40 women confirmed to have MS according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. Clinical markers including anthropometric parameters, the serum lipid profile, and glucose level were determined and analyzed with the BMD at the lumbar spine and femoral neck.
Results: There was no significant difference in femoral neck or lumbar BMD between the controls and women with MS. In correlation tests, the body mass index (BMI) showed a significant association with the femoral (r = 0.209, P ＜ 0.001) and lumbar BMD (r = 0.176, P = 0.002). In addition, the waist circumference (WC) was also significantly correlated with the femoral (r = 0.142, P = 0.012) and lumbar BMD (r = 0.113, P = 0.048).
Conclusion: The BMI and WC showed a significant positive association with the femoral and lumbar spine BMD in premenopausal women. Further studies with a large population will be needed to elucidate the combined effect of MS on BMD in middle-aged women.
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KEYWORD
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Bone mineral density, Metabolic syndrome, Middle-aged women
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